현재 임상 3상 혹은 판매중인 코로나 19 백신 종류

면역 항암제를 투여받는 환자는 보통 생백신 (=Live vaccine) 접종이 금지되어있는데, 혹시 COVID19 백신 중에 생백신은 없나 싶어서 찾아보게 되었다. 2021년 2월 9일 기준으로 WHO에서 공시해놓은 임상 3상 중이거나 생산/판매하고 있는 코로나 백신의 접근법 분류 및 그 외 코로나 백신 후보들에 대한 정보를 요약해 보았다. 

 

바이러스의 어떤 부분을 이용하는지에 따른 백신 접근법 

 

 

 

 

COVID19 백신 접근방법 

 

부서랑 팀에 공유차원에서 이메일로 보낼 때 포함했던 표를 티스토리에 붙여넣기 하려고 했더니 폰트가 내 마음대로 안나온다. ㅠㅠ 

 

COVID-19 vaccine candidates in clinical stage per approach

Platform	Candidate vaccines (no. and %)
Protein subunit	20	32%
Viral Vector (non-replicating)	10	16%
DNA	8	13%
Inactivated Virus	9	14%
RNA	7	11%
Viral Vector (replicating)	3	5%
Virus Like Particle	2	3%
Viral Vector + Antigen Presenting Cell	2	3%
Live Attenuated Virus	1	2%
Viral Vector (non-replicating)  + Antigen Presenting Cell	1	2%

 

COVID-19 vaccine or candidates at Phase 3 clinical trial or beyond  

Vaccine platform description	Type of candidate vaccine	Number of doses	Dosing schedule	Route of administration	Developers
Inactivated virus	SARS-CoV-2 vaccine (inactivated)	2	Day 0 + 14	IM	Sinovac Research and Development Co., Ltd
Inactivated virus	Inactivated SARS-CoV-2 vaccine (Vero cell)	2	Day 0 + 21	IM	Sinopharm + China National Biotec Group Co + Wuhan Institute of Biological Products
Inactivated virus	Inactivated SARS-CoV-2 vaccine (Vero cell)	2	Day 0 + 21	IM	Sinopharm  + China National Biotec Group Co + Beijing Institute of Biological Products
Viral vector (Non-replicating)	ChAdOx1-S - (AZD1222) (Covishield)	1-2	Day 0 + 28	IM	AstraZeneca + University of Oxford
Viral vector (Non-replicating)	Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)	1	Day 0	IM	CanSino Biological Inc./Beijing Institute of Biotechnology
Viral vector (Non-replicating)	Gam-COVID-Vac  Adeno-based (rAd26-S+rAd5-S)	2	Day 0 + 21	IM	Gamaleya Research Institute ; Health Ministry of the Russian Federation
Viral vector (Non-replicating)	Ad26.COV2.S	1-2	Day 0 or Day 0 +56	IM	Janssen Pharmaceutical
Protein subunit	SARS-CoV-2 rS/Matrix M1-Adjuvant (Full length recombinant SARS CoV-2 glycoprotein nanoparticle vaccine adjuvanted with Matrix M)	2	Day 0 + 21	IM	Novavax
RNA based vaccine	mRNA -1273	2	Day 0 + 28	IM	Moderna + National Institute of Allergy and Infectious Diseases (NIAID)
RNA based vaccine	BNT162 (3 LNP-mRNAs )	2	Day 0 + 21	IM	Pfizer / BioNTech  + Fosun Pharma
Protein subunit	Recombinant SARS-CoV-2 vaccine (CHO Cell)	2-3	Day 0 + 28 or Day 0 + 28 + 56	IM	Anhui Zhifei Longcom Biopharmaceutical + Institute of Microbiology, Chinese Academy of Sciences
RNA based vaccine	CVnCoV Vaccine	2	Day 0 + 28	IM	CureVac AG
Inactivated virus	SARS-CoV-2 vaccine (vero cells)	2	Day 0 + 28	IM	Institute of Medical Biology + Chinese Academy of Medical Sciences
Inactivated virus	QazCovid-in® - COVID-19 inactivated vaccine	2	Day 0 + 21	IM	Research Institute for Biological Safety Problems, Rep of Kazakhstan
DNA based vaccine	nCov vaccine	3	Day 0 + 28 + 56	ID	Zydus Cadila
Inactivated virus	Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152)	2	Day 0 + 14	IM	Bharat Biotech International Limited

*Source: WHO

 

***더 자세한 정보는 여기를 누르면 (here) WHO 웹페이지에서 읽을 수 있습니다. ***